{"id":18318,"date":"2025-12-16T20:35:59","date_gmt":"2025-12-16T20:35:59","guid":{"rendered":"https:\/\/researchchemicalsweb.com\/?post_type=product&p=18318"},"modified":"2026-02-17T14:27:30","modified_gmt":"2026-02-17T14:27:30","slug":"escaline-hydrochloride","status":"publish","type":"product","link":"https:\/\/researchchemicalsweb.com\/zh\/%e4%ba%a7%e5%93%81\/escaline-hydrochloride\/","title":{"rendered":"\u76d0\u9178\u57c3\u65af\u5361\u6797"},"content":{"rendered":"

Escaline Hydrochloride \u2013 Wetenschappelijke Productdocumentatie<\/strong><\/h3>\n

\ud83d\udd2c \u5316\u5b66\u89c4\u683c<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyfenethylamine) hydrochloride is een semi-synthetisch phenethylaminederivaat dat structureel verwant is aan mescaline. Deze onderzoeksstof wordt bestudeerd vanwege zijn interessante farmacologische profiel.<\/p>\n

\u5173\u952e\u53c2\u6570\uff1a<\/em><\/p>\n

    \n
  • \n

    IUPAC \u540d\u79f0<\/strong>: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride<\/p>\n<\/li>\n

  • \n

    \u5206\u5b50\u5f0f<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    \u5206\u5b50\u91cf<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    \u7eaf\u51c0<\/strong>: \u226598% (HPLC-UV bij 280 nm)<\/p>\n<\/li>\n

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    \u5f62\u5f0f<\/strong>: Wit kristallijn poeder<\/p>\n<\/li>\n

  • \n

    Smeltpunt<\/strong>: 243-245\u00b0C (ontleedt)<\/p>\n<\/li>\n

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    \u53ef\u6eb6\u6027<\/strong>: 50 mg\/ml in water, 30 mg\/ml in methanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea \u79d1\u5b66\u5e94\u7528<\/strong><\/h4>\n
      \n
    1. \n

      \u795e\u7ecf\u836f\u7406\u5b66\u7814\u7a76<\/strong>:<\/p>\n

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      • \n

        5-HT\u2082A receptor binding studies (Ki = 120 nM)<\/p>\n<\/li>\n

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        Vergelijkende studies met mescaline en andere phenethylamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Gedragsonderzoek<\/strong>:<\/p>\n

          \n
        • \n

          Effecten op diergedrag in gecontroleerde settings<\/p>\n<\/li>\n

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          Dosis-responsrelaties bij zoogdier-modellen<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metabolische studies<\/strong>:<\/p>\n

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          • \n

            O-dealkylatie kinetiek onderzoek<\/p>\n<\/li>\n

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            CYP2D6 interactieprofiel<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Aanbevolen Doseringen voor Onderzoek<\/strong><\/h4>\n

            \u5b9e\u9a8c\u6307\u5357\uff1a<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            \u6a21\u578b<\/th>\n\u7528\u91cf<\/th>\nAdministratieweg<\/th>\n<\/tr>\n<\/thead>\n
            \u4f53\u5916<\/td>\n10-100 \u03bcM<\/td>\nCelcultuurmedium<\/td>\n<\/tr>\n
            Kleine dieren<\/td>\n1-5 \u6beb\u514b\/\u5343\u514b<\/td>\nIntraperitoneaal<\/td>\n<\/tr>\n
            \u7075\u957f\u7c7b\u52a8\u7269<\/td>\n0,2-1 mg\/kg<\/td>\nOraal<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Let op: Dosisafhankelijke effecten boven 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Veiligheidsaspecten & Risico’s<\/strong><\/h4>\n
              \n
            1. \n

              \u6bd2\u7406\u5b66\u6570\u636e<\/strong>:<\/p>\n

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              • \n

                LD\u2085\u2080 (muis, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/dag (28-daagse studie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Bijwerkingenprofiel<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimale fysiologische effecten<\/p>\n<\/li>\n

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                  2-6 mg\/kg: Sensorische modulatie<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potenti\u00eble hemodynamische effecten<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  \u5173\u952e\u4e92\u52a8<\/strong>:<\/p>\n

                    \n
                  • \n

                    \u5371\u9669<\/strong>: MAO-remmers, serotonergische middelen<\/p>\n<\/li>\n

                  • \n

                    \u98ce\u9669<\/strong>: Vasoconstrictoren, antipsychotica<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \u8d28\u91cf\u63a7\u5236\u548c\u5206\u6790\u6570\u636e<\/strong><\/h4>\n
                      \n
                    • \n

                      \u9ad8\u6548\u6db2\u76f8\u8272\u8c31\u7eaf\u5ea6<\/strong>: 98,2% (C18-kolom, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Resterende oplosmiddelen<\/strong>: <0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      \u7a33\u5b9a\u6027\u6570\u636e<\/strong>:<\/p>\n

                        \n
                      • \n

                        Houdbaarheid: 24 maanden bij -20\u00b0C<\/p>\n<\/li>\n

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                        Kamertemperatuur: 6 maanden (onder argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 \u5e38\u95ee\u7684\u7814\u7a76\u95ee\u9898<\/strong><\/h4>\n

                        \u95ee\u9898 1\uff1a\u4f5c\u7528\u673a\u5236\u662f\u4ec0\u4e48\uff1f<\/strong>
                        \nA: Primaire werking als 5-HT\u2082A receptoragonist met secundaire effecten op dopaminerge systemen.<\/p>\n

                        Q2: Hoe verhoudt de potentie zich tot mescaline?<\/strong>
                        \nA: Ongeveer 1,5x hogere receptoraffiniteit maar langere werkingsduur (8-10 uur).<\/p>\n

                        Q3: Wat zijn optimale opslagcondities?<\/strong>
                        \nA: In amberkleurige vials onder inert gas bij -20\u00b0C.<\/p>\n

                        Q4: Zijn er genotoxische risico’s?<\/strong>
                        \nA: Ames-test negatief bij <1 mM, maar beperkte chromosoomtestdata.<\/p>\n

                        \ud83d\udccc \u7814\u7a76\u9650\u5236<\/strong><\/h4>\n
                          \n
                        • \n

                          Beperkte data over chronische blootstelling<\/p>\n<\/li>\n

                        • \n

                          Onbekende effecten op neuroplasticiteit<\/p>\n<\/li>\n

                        • \n

                          Variabele interspecies metabolisme<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Conclusie voor Wetenschappers<\/strong><\/h4>\n

                          Escaline hydrochloride biedt waardevolle mogelijkheden voor vergelijkend serotoninerg onderzoek, met een unieke combinatie van stabiliteit en werkingsduur. De hydrochloridevorm garandeert uitstekende oplosbaarheid voor laboratoriumtoepassingen.<\/p>\n

                          Belangrijke disclaimer: Dit product is uitsluitend bestemd voor wetenschappelijk onderzoek in geaccrediteerde laboratoria. Niet voor humaan gebruik of diagnostische toepassingen. Alle experimenten moeten worden uitgevoerd in overeenstemming met lokale regelgeving en ethische richtlijnen.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydrochloride eigenschappen<\/span><\/h3>\n

                          Synoniem:<\/strong> 3,5-dimethoxy-4-ethoxyphenethylamine hydrochloride
                          \nCAS Nummer:<\/strong> 39201-82-6
                          \nFormule:<\/strong> 2-{3,5-dimethoxy-4-ethyloxyphenyl}ethan-1-amine hydrochloride
                          \nMolmassa:<\/strong> 261.8 g\/mol
                          \n\u7eaf\u51c0\uff1a<\/strong> >97%<\/p>","protected":false},"featured_media":20319,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[73,239,74],"product_tag":[242,243,78],"class_list":{"0":"post-18318","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-escalin","10":"product_tag-escalin-kopen","11":"product_tag-nl","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product\/18318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/comments?post=18318"}],"version-history":[{"count":1,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product\/18318\/revisions"}],"predecessor-version":[{"id":18350,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product\/18318\/revisions\/18350"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/media\/20319"}],"wp:attachment":[{"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/media?parent=18318"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product_brand?post=18318"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product_cat?post=18318"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicalsweb.com\/zh\/wp-json\/wp\/v2\/product_tag?post=18318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}